A-431 In Vivo Metastasis Assay

This assay is to provide A-431-based In Vivo Metastasis Assay to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

A-431

Human

A-431 is a cell line exhibiting epithelial morphology that was isolated from the epidermis of an 85-year-old female patient with epidermoid carcinoma. This cell line is one of a series of cell lines established from solid tumors by D.J. Giard, et al. and can be used in cancer, toxicology, and immuno-oncology research.

A431

Epidermoid Carcinoma

Oncology

In Vivo Metastasis Assay

A-431-cell based In Vivo Metastasis Assay

Metastasis is defined as the formation of tumors that are discontinuous from the primary tumor. These secondary tumors can be at nearby or distant sites and can form, following the dissemination of cells via lymphatic, hematogenous, coelomic cavities, or epithelial cavities. Metastasis is not equivalent to invasion, adhesion, growth rate, susceptibility to immune cell killing, or any of the many steps in the metastatic cascade. These processes are necessary for successful colonization of the secondary sites, but they are not sufficient for a cell to be metastatic. Analysis of tumor growth and metastasis of human cancers requires the use of immunodeficient animals. Please contact us to learn more and offer the best-fit proposals for your program.

Oncology In Vivo Assays