This product utilizes engineered Tregs that have been engineered with our proprietary GeneCircuit technology to specifically target FAP ( clone MFP6D). We employs the pAS (SV40-mCherry-NF-κB-XbaI) vector components and the SynExpress system of the single base pair Base Editing/Delayed feedback for a robust and sustained response against cancers.
Host
Human
Target
FAP
Clone
MFP6D
Species Reactivity
Human
Cell Source
Engineered Tregs
Sensor Gene
mCherry
Promoter
SV40
Effector Gene
NF-κB
Insertion Sites
XbaI
Gene Modification
Base Editing
Modification Domain
Single base pair
Carrier Type
pAS
Transformation Accuracy
0.85
Cell Culture
3D Culture
Target
FAP
Alternative Names
FAP; DPPIV; FAPA; SIMP; fibroblast activation protein alpha; FAPalpha
All cell products are transported using dry ice, or specialized refrigerated containers to ensure that their temperature remains within an appropriate range. For cell products that are particularly sensitive to temperature, transportation must be carried out in liquid nitrogen tanks to ensure the quality and viability of the products.
Handling Advice
Handle cells in a sterile environment to prevent contamination. Use aseptic techniques when transferring to new media or containers. Follow biosafety regulations for disposing of cell waste.
Storage
Keep cell products in the designated temperature range (usually liquid nitrogen or -80°C) to maintain viability.