This program aims to develop anti-GPVI therapeutic monoclonal antibody for immuno-oncology.
Tumor vascular integrity is essential for tumor growth, thus affecting tumor progression. Previous studies have determined that platelets are targets of potential anti-tumor therapy and major regulators of tumors. Studies have also shown that platelet glycoprotein (GP) VI (GPVI) is a key regulator of vascular integrity in tumor growth, which can induce tumor hemorrhage and reduce tumor growth without causing systemic bleeding complications. These data fully indicate that GPVI could be a promising target for next generation cancer immunotherapy.
Glycoprotein (GP) VI, a platelet receptor for collagen, laminin and fibrin, is a type 58 transmembrane protein with 58-60 kDa molecular weight. It mainly regulates a variety of platelet functions, including adhesions, activation, aggregation, and procoagulant activity.
Highlight functions of GPVI:
Fig.1 Impact of the interaction between GPVI and galectin 3 on cancer metastasis. (Schlesinger, 2018)
Here are some published data about GPVI molecule work as a potential target for cancer immunotherapy.
(Volz, 2019)
(Schuhmann, 2019)
Currently, several studies of GPVI therapeutic mAbs are undergoing early clinical trials for the treatment of thromboembolic disorders. Accumulating preclinical evidence supports their clinical development. However, further studies are needed to identify the efficacy, safety, and combination strategies of GPVI therapeutic mAbs in cancer.
Looking ahead, GPVI owns a promising market prospect in the future. In particular, there are increasing interests in combining anti-GPVI with other agents, thus representing a particularly promising approach to achieving greater therapeutic success in treating various cancers.
We have extensive experience in end-to-end program development. For each program, we are committed to delivering the final complete program to our clients within 1.5 years prior to entering the IND stage.
Creative Biolabs is looking for potential partners (include but not limit to major pharma or biotech firms) to develop anti-GPVI therapeutic monoclonal antibody program together. Our scientists are dedicated to bringing together years of valuable experience to our partner and achieve a meaningful partnership. By doing so, we wish to help both parties to proceed with IND and many stages of clinical trials beyond.
If you are interested, please feel free to contact us so that we can discuss the program and other possible opportunities for cooperation. Look forward to working with you in the near future.
For Research Use Only | Not For Clinical Use