Antibody Engineering Services
Introduction Featured Services Workflow Publication Why Choose Us FAQs Customer Review Related Services Contact Us
Creative Biolabs provides comprehensive, end-to-end therapeutic antibody discovery and development services. Their portfolio includes antibody discovery, engineering, production, and characterization, as well as bioassays and in vivo testing, all designed to accelerate your cancer immunotherapy program.
Revolutionizing Medicine: The Power of Antibody Engineering
Antibody engineering, a cornerstone of modern biopharmaceutical development, precisely modifies antibodies to enhance their therapeutic potential. Leveraging deep insights into antibody structure-function relationships, this field addresses critical challenges like immunogenicity, suboptimal binding, and the need for novel functional properties. As a fast-developing and popular drug type, therapeutic antibodies especially monoclonal antibodies have attracted attention of researchers and pharmaceutical industries. Creative Biolabs is dedicated to the antibody engineering field for decades and establishing a series of platforms including various antibody engineering services. A wide range of formats are available for antibody engineering including IgG, Fab, scFv, CARs, bispecific antibody, etc. for therapeutic use.
Our Antibody Engineering Services
As a leading supplier of antibody engineering for immunotherapy and tumor research, our antibody engineering team provides an independent and comprehensive service portfolio including antibody reformatting and production, epitope binning and mapping, antibody humanization, affinity maturation, affinity measurement, sequence liability identification, immunogenicity prediction, therapeutic developability assessment, and other antibody specialization and modification services. For detailed information about our antibody engineering services, please visit the following modules. If you are interested in any other specific requirements, please feel free to contact us to tailor a custom service for you.
Antibody Reformatting and Production
Creative Biolabs offers premier antibody reformatting and production services, transforming your early-stage discoveries into functional therapeutic or diagnostic antibodies. Our expertise ensures seamless conversion into desired formats, accelerating your path to market with high-quality, scalable solutions.
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Epitope Binning and Mapping
Epitope binning and mapping are crucial for therapeutic antibody development, identifying binding sites and mechanisms of action. Creative Biolabs offers comprehensive services to define challenging epitopes on diverse targets, aiding novel biologic discovery.
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Affinity Measurement
Creative Biolabs offers various platforms to measure antibody/protein-ligand affinity, crucial for understanding molecular interactions. Their extensive experience ensures flexible technology choices to determine kinetic properties and binding affinity, defined by thermodynamic principles.
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Sequence Liability Identification
Creative Biolabs, a therapeutic antibody discovery leader, offers a powerful engineering platform. Services include reformatting, production, epitope binning/mapping, humanization, maturation, affinity measurement, sequence liability identification, immunogenicity prediction, developability analysis, and other specialization/modification services.
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Immunogenicity Prediction
Immunogenicity, the ability of biologics to induce immune responses, is a critical safety concern. Creative Biolabs developed sensitive immunogenicity assessment technology (SIAT), in silico and in vitro, to address this. It quantifies biologics, measures anti-drug antibodies (ADAs), and assesses PK/PD efficacy.
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Therapeutic Developability Assessment
Higher drug development costs and lower approval rates necessitate early candidate screening. Creative Biolabs offers therapeutic development assessment services to mitigate risks, reduce costs, and accelerate R&D timelines, helping clients navigate drug discovery and de-risk pipelines.
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Antibody Humanization
Recombinant antibodies show clinical success, but murine mAbs have immunogenicity issues. Humanized antibodies reduce this, making them promising alternatives. Creative Biolabs offers customized antibody humanization services with various methods and toolkits.
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Antibody Maturation
Antibody affinity maturation improves antibody potency for research, diagnosis, and therapeutics. Creative Biolabs offers antibody optimization and affinity maturation services, combining molecular evolution with high-throughput phage library screening, enhancing potency and reducing production costs.
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Comprehensive Antibody Engineering Workflow
Our antibody engineering workflow is designed for clarity, efficiency, and optimal results, providing a transparent and collaborative path for your project.
Required Starting Materials for Project Initiation:
To initiate your antibody discovery project, we typically require:
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Target antigen information: Provide sequence, structural data, and expression details for your target. This helps design specific antibodies.
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Parental antibody sequence: If you have an existing lead, provide its full heavy and light chain sequences to enable modifications like humanization or affinity maturation.
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Project objectives and desired antibody profile: Clearly define your therapeutic goals, including desired affinity, effector function, therapeutic indication, and preferred final antibody format.
Key Steps Involved:
Final Deliverables Upon Project Completion:
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Purified, engineered antibody constructs.
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Detailed characterization reports.
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Developability profiles & expert recommendations.
Publication
This publication reviews the fundamental understanding of antibody structure and how this knowledge enables the engineering of therapeutic antibodies and related biologics. It discusses platforms for developing antibodies, antibody fragments, bispecific antibodies, and antibody fusion products, emphasizing how humanization, affinity modulation, and stability enhancement can improve their efficacy and manufacturability. The review also covers the design and selection of binding arms, avidity modulation, and strategies for preparing bispecific and multispecific molecules for various therapeutic applications.
Fig.2 Ribbon diagram of mouse IgG2a.1
Why Choose Us?
Creative Biolabs stands at the forefront of antibody engineering, offering unparalleled advantages that set your project apart. Our commitment to scientific excellence, combined with our innovative platforms and deep expertise, ensures superior results and accelerated progress for your therapeutic development.
Highlights:
✔ Rich experience and expertise in the antibody engineering field.
✔ Guaranteed quality to ensure high affinity, specificity.
✔ Strategy diversity to meet your specific requirements.
✔ State-of-the-art equipment and platforms.
Ready to optimize your antibody's affinity? Request a detailed proposal today.
FAQs
Q1: What types of antibodies can Creative Biolabs engineer, and what novel formats do you offer?
A1: Creative Biolabs offers comprehensive engineering services for a wide range of antibody formats, including full-length IgGs, Fab fragments, scFv, minibodies, and complex bispecific and multispecific antibodies. Our capabilities extend to pioneering novel formats like i-shaped antibodies.
Q2: Can Creative Biolabs help improve the binding affinity of my existing antibody lead?
A2: Absolutely. Our affinity maturation services utilize robust platforms combining molecular evolution with high-throughput screening, such as phage display. We can precisely tune your antibody's binding strength to its target, leading to enhanced potency and reduced dosage requirements in a remarkably efficient timeframe.
Q3: What if my target receptor is difficult to agonize with traditional antibodies or requires specific conformational activation?
A3: This is a common challenge for many therapeutic targets, and it's where our innovative conformational engineering, including i-shaped antibody (iAb) technology, truly shines. By precisely tuning the antibody's conformation, we can enable intrinsic agonistic activity even for receptors.
Customer Review
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Accelerated Lead Optimization
Creative Biolabs' comprehensive approach to developability optimization has been a game-changer for our early-stage leads. Their predictive tools and tailored engineering strategies allowed us to identify and mitigate potential aggregation and stability issues long before in vivo studies, significantly accelerating our lead optimization phase. - Dr. Emily V****s
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High-Quality Recombinant Antibody Production
For our demanding research, obtaining high-quality recombinant antibodies is paramount. Creative Biolabs consistently delivers. Their expression and purification services provide highly pure, functionally active antibodies with excellent batch-to-batch consistency. - Dr. John C****y
Related Services
To further support your therapeutic development goals, Creative Biolabs offers a suite of complementary services and specialized variations of our antibody engineering expertise, ensuring a holistic approach to your project:
Next CAR-T Manufacturing
Creative Biolabs is an experienced pharmacological CRO specializing in cellular and gene therapy. We offer customized, flexible solutions and progress reports at any development stage, acting as an extension of your lab to meet clinical research and therapeutic needs.
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Protein Binding Analysis Service
In vitro protein binding assays characterize drug distribution by revealing drug affinity for plasma, serum, blood, microsomes, and tissue. This insight into protein binding helps predict a drug's pharmacokinetic profile and therapeutic effects.
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Contact Us
With extensive experience, rich industry knowledge, and advanced antibody engineering technologies, Creative Biolabs is exactly competent in a full spectrum of engineering services. We are confident in accomplishing even the most challenging engineering project with a quick turnaround time. To learn more, please don't hesitate to contact us to learn how we can help you with your project.
Reference
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Chiu, Mark L., et al. "Antibody structure and function: the basis for engineering therapeutics." Antibodies 8.4 (2019): 55. Distributed under Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.3390/antib8040055
