C1498 In Vitro Telomere Length Analysis Assay (Senescence)

This assay is to provide C1498-based In Vitro Telomere Length Analysis Assay (Senescence) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

C1498

Mouse

C1498 is a murine myeloid leukemia cell line isolated from a C57BL/6J mouse. It most closely resembles acute myeloid leukemia (AML), and is highly lethal when implanted into syngeneic mice.

Acute Myeloid Leukemia; AML

Oncology

In Vitro Telomere Length Analysis Assay (Senescence)

C1498-cell based In Vitro Telomere Length Analysis Assay (Senescence)

For the analysis of telomere length, terminal restriction fragment anal ysis technique has been the commonly used technique for a long time.

Cellular Senescence in Cancer Assays

Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.

Telomere Length Analysis Assay