Short Description
Quantifies compound permeability through an artificial gastrointestinal membrane using a spectrophotometric method.
Development Stage
Research-Grade Cell-Based Assay Development
Description
The CelluTest™ Parallel Artificial Membrane Permeability Assay (PAMPA) Kit offers a cost-effective, high-throughput solution for evaluating the gastrointestinal permeability of drug candidates. This system mimics passive diffusion across biological membranes, providing essential absorption data in early-stage drug discovery. By enabling rapid screening of thousands of compounds, it accelerates lead optimization and enhances predictive accuracy in pharmaceutical development.
Features
Rapid High-Throughput Efficiency: Streamline lead optimization by evaluating thousands of compounds daily using automated 96-well plate formats for maximum productivity.
Cost-Effective Passive Screening: Achieve reliable permeability rankings at a fraction of the cost and time required for labor-intensive cell-based assays.
Versatile Membrane Customization: Adapt lipid compositions to accurately simulate gastrointestinal, blood-brain barrier, or skin environments for diverse tissue-specific penetration studies.
Broad pH Compatibility: Assess ionizable compound stability and absorption kinetics across a wide physiological pH range to predict regional intestinal uptake.
Process Relevance
Predicting passive diffusion rates to identify poorly permeable leads early, preventing costly late-stage clinical attrition and developmental delays.
Application Stage
Early-stage drug discovery, lead optimization, and high-throughput ADME profiling during preclinical development for candidate ranking and selection.
Applications
This kit facilitates gastrointestinal absorption modeling, blood-brain barrier penetration studies, and skin permeability assays for compound ranking, excipient research, and passive diffusion kinetic analysis.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Target
Small molecule chemical compounds and pharmaceutical candidates utilizing passive transcellular diffusion for biological membrane transport.
Sample Type
Chemical compounds
Research Areas
Pharmacokinetics (ADME), transdermal drug delivery, neuropharmacology, gastrointestinal therapeutics development, etc.
Datasheet