The gut microbiome holds great promise for the development of novel disease biomarkers and therapeutics. Creative Biolabs serves you with the logistics of your gut microbiome analysis project. We provide a culture-based approach to help you analyze and characterize gut microbiota.
Culture-based methods have been the workhorse of clinical microbiology for almost a century. In vitro microbial systems, including ones that contain host cells in the microbial culture, have the longest history, are widely available, and present one of the most controllable environments for mechanistic and molecular profiling. These included growing and isolating individual organisms followed by phenotypic or genotypic analysis.
Initially, culture and biochemical typing were the standard methods to identify any new bacterial species. However, it is well known that more than 40% of gut microbes cannot grow outside the natural environment. But the currently used culture-based methods have the advantage of quantifying absolute cell abundances of the culturable living microbes. To know more about the human gut microbes’ diversity, their compositions, and relationships with various diseases, thus, many other techniques are also developed. More recently, many culture techniques, for example, gel microdroplets, microculture, and microbial chips, provide very diverse growth conditions; hence, a large number of unknown microbes can grow. A few recent studies have attempted to characterize the culturable human gut microbiota by combining culture with next-generation sequencing. The combination of both cultivation and metagenomic analysis is key in studying the species' ecological niche and the drivers forcing its evolution.
At Creative Biolabs, our scientists are creating new solutions to help you the culture and/or identify microbes for the characterization of microbial communities. We create and build tailored, proprietary culture collections with previously unknown microbes. We identify novel bacterial strains based on functional traits at speeds and volumes never previously seen. Many culture-based techniques provide you with a better understanding of gut microbiota.
Fig.1 Culturing the human microbiota and culturomics. (Lagier, 2018)
The longest-standing in vitro technique for studying host-associated microorganisms is microbial culture. Based on a gut microbiota-based diagnostics platform, Creative Biolabs has established microbiology laboratories to culture and analyze gut microbiota. We own oxygen or oxygen-free environment, as well as specialized reagents and many instruments. We provide conventionally and sequencing approaches for further analysis. If you are interested in analyzing microbiota as part of your clinical or academic research, please contact us for further information.
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For Research Use Only | Not For Clinical Use
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