With the rapid progress of various immunotherapies, especially the therapeutic antibodies, the discovery and development of potential anticancer immunotherapy approaches has become a promising direction. Creative Biolabs is dedicated to offering a comprehensive set of standalone or integrated services to support preclinical testing, including in vivo pharmacology, drug metabolism and pharmacokinetics, toxicology as well as efficacy models.

Background

Even though many cancer immunotherapies offer fresh hope for cancer patients, only a small portion of cancer patients can be cured by immunotherapies. New immunotherapies need to be explored urgently. For a potential drug candidate, safety and efficacy data needs to be evaluated before exposure to humans. To assess the antitumor efficacy in animal models, specific oncology efficacy models need to be established.

Fig.1 Integrated services for preclinical testing.

Our Efficacy Models

As an end-to-end solution provider and concentrated CRO in cancer immunotherapy discovery and development, Creative Biolabs offers comprehensive suite of validated oncology in vivo models for our clients to advance their preclinical development projects in a cost-effective and timely manner. We are committed to helping you choose the most appropriate efficacy model, design studies, and screen assays matched to your drug candidates including checkpoint inhibitors, co-stimulatory agonists, viruses, therapeutic engineered immune cells, cytokines and antibodies.

Models Under Development

In this diverse oncology therapeutic field, we understand that the above models will not meet all needs, therefore we are always under development with a wide range of models for our clients to evaluate the preclinical efficacy data of the immunotherapy approaches such as humanized models. We will work with you closely to customize a specific model to best meet your needs.

Highlight Features

• ✔ More than 50 diverse human cancer cell lines for xenograft models,
• ✔ Reproducible and accurate efficacy data,
• ✔ Regulatory experts’ guidance to ensure compliance.

With extensive experience and expertise technicians, Creative Biolabs has established comprehensive efficacy models to facilitate in vivo efficacy evaluation for new potential immunotherapeutic. Please don’t hesitate to contact us for our experts’ advice about choosing the appropriate efficacy model to best fit your needs.