Aptamers are single-stranded nucleic acid molecules that can fold into complex three-dimensional structures, forming binding pockets and clefts for the specific recognition and tight binding of any given molecular target. In recent years, aptamers have attracted much attention because they have all of the advantages of antibodies. The adoption of the aptamer is well on the rise, serving an ever-increasing demand for versatility in the biomedical field.
Creative Biolabs is a leading service provider for generating aptamers that are capable to bind with tissue targets or cell targets. We are experienced to discover aptamers targeting proteins located on the cell surface. To assess the effect of the RNA aptamers, RNA coimmunoprecipitation assay, soft agar colony formation assay and cell proliferation assay will be performed. After an aptamer is selected we suggest specific modifications to improve its properties based on their applications, including cell delivery, nuclease resistance, and duplex stability. Moreover, biotinylation, fluorophores, and backbone modifications are all available. We offer high-quality negative selection service, aptamer-based precipitation service, aptamer-based sensor development service and custom aptamer-based microarray service, allosteric/structure-switching aptamer development service.
Engineering cancer cells with target-specific aptamer is a promising try for cancer immunotherapy. Multiple genetic methods for cell line engineering, including retrovirus, lentivirus, adenovirus, adeno-associated virus, and CRISPR-based methods are considered. Research scientists at Creative Biolabs are experts in Cancer Cell Engineering with target-specific aptamer. We will assist our global clients based on their specific requirements. We provide efficiencies with shorter timelines to accelerate our clients’ cancer immunotherapy development projects.
RNA aptamer is a useful tool for obtaining further insight into the functional properties of peroxisome proliferator-activated receptor δ (PPR-δ). Creative Biolabs has accumulated rich experience in aptamer screening, our scientists are proficient at selecting high-affinity PPAR-δ–specific RNA aptamers and engineering cancer cells with PPAR-δ-specific aptamer.
Since β-catenin is an excellent target for cancer therapeutics, scientists at Creative Biolabs have studied this protein for many years. Creative Biolabs has accumulated rich experience in selecting high-affinity β-catenin–specific RNA aptamers and engineering cancer cells with RNA aptamers.
Development of nucleolin-binding aptamers is an efficient strategy to inhibit tumors. Equipped with a team of seasoned experts in aptamer development, Creative Biolabs offers fast and reliable support for every phase in nucleolin-specific aptamer selection and quality control. Moreover, we offer highly customized cancer cell engineering services.
R&D facility at Creative Biolabs is fully equipped with modern laboratory spaces. Our scientific expertise provides highly customized solutions to meet every specific demand in engineering cancer cells with target-specific aptamer. For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
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