Creative Biolabs is committed to providing comprehensive and professional services for engineering prostate cancer cells, from proof of concept to process development. Our scientists are proud to bring you a wide array of cell engineering platforms as well as accompanying technical expertise to help meet your project needs.
A variety of efforts are underway to apply gene therapy to cancer treatment. An attractive approach has a great deal of promise to kill cancer by modifying tumor cells instead of T cells. Therapeutic models using gene transfer into tumor cells can induce:
Modulation of cytokines is one of the strategies for cancer therapy. To circumvent the problems associated with systemic injection of cytokines, a new approach has emerged in recent years. Localized secretion of cytokines mediated via gene transfer can induce potent anti-tumor immune responses. The expression of certain cytokine genes by tumor cells has been shown to increase tumor immunogenicity and has led to primary rejection of transfected tumor cells by syngeneic hosts as well as to the induction of a systemic, cellular antitumor immune response.
Fig.1 Role of cytokines in prostate cancer. (Mao, et al., 2021)
The clinical course of prostate cancer is grouped into two broad phases: androgen-dependent prostate cancer (ADPC) and androgen-independent prostate cancer (AIPC) or hormone-refractory prostate cancer. Prostate cancer cell lines produced from cancer cells are models to better understand cancer and to develop novel therapies that are common in research. DU145, PC3, LNCaP, and 22Rv1 were commonly used cell lines with different biological characteristics in therapeutic research. Now, Creative Biolabs has established a platform to engineer prostate cancer cell lines expressing cytokines for cancer therapy research. We are committed to offering the most complete prostate cancer cell lines with genetic modifications to meet your needs. We are still trying to expand our cell line repository to better support your research.
Creative Biolabs has the ability to complete your cell engineering projects in far less time. The custom-engineered cell lines can be developed by different gene delivery technologies, such as viral transduction (retrovirus, lentivirus, adenovirus, adeno-associated virus), or non-viral delivery systems. In addition, gene editing via the CRISPR system has enabled more precise genetic manipulation to optimize cell engineering and function.
The involvement of various cytokines and their signaling pathways in the promotion of tumor growth and metastasis has been well-studied in prostate cancer. We have developed engineered prostate cancer cells for stronger T-cell activation. The following are some different strategies you can choose to engineer.
We can engineer custom prostate cancer cell lines with a wide selection of cytokines including VEGFC, VEGF165, TNF-α, etc.
We can engineer prostate cancer cell lines with Target-specific aptamer including PPAR-δ-specific aptamer, β-catenin-specific aptamer, nucleolin-specific aptamer...
Aptamers can be used for delivering therapeutic oligonucleotides, such as siRNA. We can engineer custom prostate cancer cell lines with a aptamer-siRNA...
We provide a immunomodulatory gene circuit platform that enables tumor-specific expression of immunostimulators…
RNAi is an economic, fast, and efficient method of cancer therapy. We are proficient at engineering prostate cancer cell lines with targeted siRNA delivery for cancer.
Creative Biolabs provides a one-stop platform for the development of engineered cancer cells for self-destruction, from cell development to in vitro & ex vivo assessment. Our custom cell services team can handle all aspects of your cell engineering workflow, from start to finish. We make design recommendations based on your requirements to save you time and hassle. If you are interested, please feel free to contact us to discuss your project.
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For Research Use Only | Not For Clinical Use
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