Based on our advanced Ex Vivo Immune Reactivity Assessment platforms and powerful technology, Creative Biolabs provides a complete range portfolio of assays for the production measurement of cytokines and chemokines. To meet the service you need, our highly skilled scientists are ready to get started on your projects.
Cancer vaccine is a type of adaptive immunotherapy by engineering cancer cells with self-destruction strategies. Cancer vaccines could achieve good effectiveness in the treatment of cancer, by inducing extensive local lymphangiogenesis and promoting stronger T cell activation. The cancer antigens as candidates for the vaccine could be recognized and processed to antigen-specific lymphocytes by presenting cells. The activated immune cells, especially T cells, assume effectors such as cytokine and chemokine to inhibit cancer progression. Thus, the immune reactivity could be accessed by ex vivo measurement of cytokine and chemokine production, which plays a central role in the regulation of the proliferation, differentiation, and immune memory of T cells.
Fig.1 Proposed model for VEGFC vax Cancer vaccine mechanism of action. (Sasso, et al., 2021)
An inescapable problem of cancer immunotherapy that must be addressed is the negative effects of unexpected inflammation and cytokine storm syndrome, resulting in tissue damage and inflammatory cell infiltration. Cancer patients with malignant tumors are often characterized by rapidly and dramatically elevated high levels of cytokines and chemokines, such as MCP-1/CCL2, MIP-1α/CCL3, IL-8, and IP-10/CXCL10. Qualification of cytokine and chemokine with our ex vivo measurement services may help researchers evaluate and minimize the lethal risks of uncontrolled inflammation and cytokine storm syndrome.
Our ex vivo immune reactivity assessment service may help acquire good candidate cancer antigens and verify whether the candidate could work well as a cancer vaccine and achieve efficient anti-tumor immune effects. In the early stage of vaccine development, this assessment could help dose optimization to maximize the treatment effects of cancer vaccines while helping avoid the cytokine storm syndrome resulting from booster vaccination.
Through analysis of cytokine and chemokine signature features, you could comprehend the systemic role of the cytokines and chemokines at different stages during vaccine therapy. On this basis, we will identify the biomarkers of successful vaccination, by our ex vivo immune reactivity assessment service, which will result in efficient cancer vaccine development. Ultimately, Our ex vivo immune reactivity assessment service is an important tool for the valuation of the immune effect of cancer vaccines with the Self-destruction strategy.
Compared with in vivo immune reactivity assessment, our ex vivo monitoring of the immune responses has many advantages including lower risk, higher efficiency, and fewer technical difficulties. With decades of in-depth study of this ex vivo immune reactivity assessment area, we are one of the most potent professional technical developers.
With the in-depth study of cytokine, Creative Biolabs provides advanced custom analytic service through the upgraded combination of our software and multiplex analyzers. The lab of Creative Biolabs is equipped with the automated full wavelength spectrofluorometer, fluorescence microscopes, real-time quantitative PCR instrument, and a couple of flow cytometers with multiple lasers and fluorescent channels.
Our experienced experts at Creative Biolabs will complete your project for the ex vivo immune reactivity assessment service you needed. If you are interested in this, please feel free to contact us directly.
Reference
For Research Use Only | Not For Clinical Use
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