GCLC-targeted RNA Modification and Metabolomics Analysis Tool

CAT#: ITS-0524-CR8
Cell Type: MDSCs
RNA writers: METTL4
RNA readers: /
RNA erasers: FTO
Enzymes: HDACs
RNA types: mRNAs
Modification: m6A
RNA editing: T to C
Short Description
This product is a GCLC-targeted RNA modification and metabolomics analysis tool based on the m6A (METTL4-FTO-HDACs-phos) modification and PPP-mediated (PRPF8-Lactyl-CoA-ATP) metabolic analysis system.
RNA writers
METTL4
RNA readers
/
RNA erasers
FTO
Enzymes
HDACs
RNA types
mRNAs
Modification
m6A
Label
phos
RNA editing
T to C
Cell Type
MDSCs
Oligonucleotide
PS, 2'-OMe, 2'-F, GalNAc
RNA Construction
mRNAs-m6A-METTL4-FTO-HDACs-phos
Substrates
Lactyl-CoA
Cofactors
ATP
Pathway
PPP
Epigenetic regulator
ACLY overexpression
Metabolic alteration
Increasing the content of acetyl-CoA
Targeting diseases
Adrenocortical carcinoma
RNA-binding proteins
PRPF8
Metabolic Reprogramming
PPP-PRPF8-Lactyl-CoA-ATP
Target
GCLC
Alternative Names
GCLC; GCL; GCS; GLCL; GLCLC; glutamate-cysteine ligase catalytic subunit
Gene ID
2729(Human); 14629(Mouse); 25283(Rat)
UniProt ID
P48506(Human); P97494(Mouse); P19468(Rat)
Format
Liquid
Shipping
All ordered products are shipped from Fedex or UPS.
Handling Advice
Prevent prolonged exposure to light.
Storage
Recommended long-term storage in - 20 ° C, to ensure the longest shelf life of products.
For Research Use Only | Not For Clinical Use
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