GL261 In Vitro LDH Assay (Cell Viability)

CAT#: ITS-1022-YF220
Target Cell Organism: Mouse
Target Cell Alternative Name: Glioma 261
Target Cell Name: GL261
Assay Type: Cell Viability/Cytotoxicity and Antiproliferative Assays
Assay Overview
This assay is to provide GL261-based In Vitro LDH Assay (Cell Viability) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.
Target Cell Name
GL261
Target Cell Organism
Mouse
Target Cell Background
Glioma 261 (GL261) is a frequently used murine glioma model. It was induced via intracranial injection of methylcholanthrene followed by serial intracranial and subcutaneous transplantations of tumor fragments into syngeneic C57BL/6 mice. By the mid-1990s, multiple groups had established a permanent cell line from the tumor.
Target Cell Alternative Name
Glioma 261
Related Diseases
Glioma
Research Area
Oncology
Assay Name
In Vitro LDH Assay (Cell Viability)
Short Description
GL261-cell based In Vitro LDH Assay (Cell Viability)
Assay Description
Lactate dehydrogenase leakage assay (LDH assay) can also be used to determine viability of cancer cells. Upon treatment with a testing drug, if the drug can rupture the cell membrane, cells release LDH to the culture medium and released LDH can be quantified.
Assay Alternative Names
Lactate Dehydrogenase Leakage Assay
Assay Type
Cell Viability/Cytotoxicity and Antiproliferative Assays
Assay Type Details
Uncontrolled proliferation is one of the main features of cancer cells. Cell-based in vitro assays are employed to determine whether test molecules possess direct cytotoxic/antiproliferative effects in cancer cells.
Assay Subtype
Cell Viability Assay
Assay MOA
Cell-based Viability Assays Based on Cellular Enzymes and Proteins
For Research Use Only | Not For Clinical Use
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