The GuardianOx™ Bilirubin Assay Kit differentiates between total and direct bilirubin, allowing for the specific identification of cholestatic potential in new drug candidates. This assay is a cornerstone of liver safety assessment, helping to distinguish between hepatocellular injury and biliary obstruction. It supports pre-clinical toxicology by verifying that compounds do not impair bilirubin conjugation or excretion.
Features
Differentiates total and direct bilirubin; Critical for identifying cholestatic potential of new drug candidates.
Process Relevance
Hepatotoxicity (Cholestasis)
Application Stage
Pre-clinical Safety
Applications
Diagnosis of jaundice and liver function monitoring.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 530 nm
Sample Type
Serum
Research Areas
Hepatology; Hematology
Size
180 tests
Data Output Type
Quantitative (Concentration)
Assay Time
Results in 10 min
LOD
0.16 mg/dL
Species
All Species
Storage
Store at 4 °C upon receipt to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid freezing unless otherwise specified. During use, minimize prolonged exposure to room temperature and return components promptly to 2-8 °C storage after handling. Do not store at elevated temperatures for extended periods.
Expiry Date
12 months under recommended storage conditions to ensure optimal performance.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Bilirubin is a yellow pigment formed from heme breakdown. Elevated levels (jaundice) differentiate between pre-hepatic (hemolysis) hepatic (liver damage) and post-hepatic (obstruction) etiologies.