Development Stage: Research-Grade Oxidative Stress Assay Development
Short Description
Simultaneous determination of protein and creatinine.
Brand
GuardianOx
Development Stage
Research-Grade Oxidative Stress Assay Development
Description
The GuardianOx™ Protein Creatinine Ratio Assay Kit provides a dual assay format to standardize the assessment of proteinuria, a key marker of nephrotoxicity in preclinical trials. This assay validates the renal safety of new drug candidates by normalizing protein excretion to creatinine levels. It offers a convenient, non-invasive method for monitoring kidney function in longitudinal animal studies.
Features
Dual assay format; Standardizes proteinuria assessment for nephrotoxicity in preclinical trials.
Process Relevance
Renal Toxicity Profiling
Application Stage
Pre-clinical Safety
Applications
Assessment of proteinuria and kidney health.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 600 and Absorbance at 530 nm
Sample Type
Urine samples
Research Areas
Nephrology; Toxicology
Size
100 tests
Data Output Type
Ratio Metric
Assay Time
Results in 10 min
LOD
Protein: 1 mg/dL; Creatinine: 1 mg/dL
Species
All Species
Storage
Store at −20 °C upon receipt to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. During use, minimize the time components are exposed to room temperature and return them promptly to −20 °C storage after handling. Do not store at elevated temperatures for extended periods.
Expiry Date
12 months under recommended storage conditions to ensure optimal performance.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
The Urine Protein to Creatinine Ratio (UPCR) estimates 24-hour protein excretion from a spot urine sample. It is the standard method for screening proteinuria correcting for urine concentration.