The human gut microbiome contains as many bacterial, archaeal, and eukaryotic microbes as the number of human cells in the body. They play an important role in health and disease and can be viewed as a mirror of the host physiology. Enriched experience associated with state-of-the-art facilities, Creative Biolabs has long-term devoted to the discovery and development of gut microbial biomarkers, and the identification of populations at risk of special human disease.
Preclinical studies have shown that the gut microbiota can play a role in SCH pathogenesis via the gut-brain axis. SCH patients may present characteristic microbiota, and certain microbiota biomarkers may predict treatment response in this patient population. The associations between the gut microbial compositions and the risk of SCH have also been reported in several psychiatric patient studies. Patients with SCH display a dysbiosis of gut microbiota. Moreover, several microbial biomarkers, such as genera Lactobacillus, family Lachnospiraceae, Ruminococcaceae, Veillonellaceae, and Streptococcaceae, have been identified, which are significantly correlated with symptom severity.
The gut microbiome is a diverse ecosystem with multiple metabolic and immune functions associated with the host diet and lifestyle. Therefore, considering the current variety of diets and lifestyles in human society, there are drivers of the gut microbiome yet to be accessed and explored to understand how they affect this ecosystem. T2D is linked both with host genetics and with dysbioses of the gut microbiota. Some T2D-related microbiota biomarkers have been identified. They may represent not only novel markers for early diagnosis but also a target for preventative therapeutic intervention.
Fig.1 Study design for sub-clinical gut microbiome analysis in obesity and type 2 diabetes. (Yassour, 2016)
Gut Microbiota Genomic Analysis
We are dedicated to offering high-quality gut microbiota genomic analysis services, including 16S ribosomal RNA sequencing, shotgun metagenomic sequencing, single-cell genome sequencing, and whole-exome sequencing.
Gut Microbiota Single-cell Transcriptional Profiling
We are fully competent and dedicated to serving as your one-stop shop for gut microbiota single-cell transcriptional profiling.
Gut Microbiota Metatranscriptomic Analysis
We have perfected our technical pipelines for gut microbiota metatranscriptomic analysis.
Gut Microbiota Metaproteomic Analysis
We are pleased to share our cutting-edge technology in gut microbiota metaproteomic analysis.
Gut Microbiota Metabolomic Analysis
We offer highly customized gut microbiota metabolomics services to meet every specific requirement.
Quantitative Microbiome Profiling
We own a group of scientists who are pleased to share expertise and experience in quantitative microbiome profiling.
Gut Microbiota Bioinformatics Analysis
Learn more about our gut microbiota bioinformatics service.
Direct Mass Spectrometry
We have rich experience in the field of performing direct mass spectrometry for gut microbial biomarker identification.
Immunoprecipitation & Mass Spectrometry
Learn more about our immunoprecipitation & mass spectrometry for gut microbial biomarker identification service.
Protein Array
We have extensive experience in applying protein array for gut microbial biomarker identification.
Creative Biolabs has a long-term devoted to biomarker discovery and development. We provide a one-stop solution for gut biomarker discovery, including sequence-based technologies and no-sequence-based technologies. Our technologies provide a powerful method for aggregating gut microbiome to perform differential abundance analysis.
The gut microbiome performs metabolic functions, protects against pathogens, and engages in a range of human diseases, particularly with the immune system and the gut-brain axis. Creative Biolabs is fully competent and dedicated to characterizing gut microbial signatures of various human diseases, and identifying microbial biomarkers. For more detailed information, please feel free to contact us.
Reference
For Research Use Only | Not For Clinical Use
Download our brochure