HIF-1-targeted RNA Modification and Metabolomics Analysis Tool

CAT#: ITS-0524-CR70
Cell Type: M2 macrophages
RNA writers: TRMT6/61A
RNA readers: YTHDF1/2/3
RNA erasers: ALKBH7
Enzymes: PDH
RNA types: mRNAs
Modification: ac4C
RNA editing: A to I
Short Description
This product is a HIF-1-targeted RNA modification and metabolomics analysis tool based on the ac4C (TRMT6/61A-YTHDF1/2/3-ALKBH7-PDH-TET) modification and Mevalonate pathway-mediated (MBNL-SAM-ADP) metabolic analysis system.
RNA writers
TRMT6/61A
RNA readers
YTHDF1/2/3
RNA erasers
ALKBH7
Enzymes
PDH
RNA types
mRNAs
Modification
ac4C
Label
TET
RNA editing
A to I
Cell Type
M2 macrophages
Oligonucleotide
PS, 2'-OMe, 2'-F, GalNAc
RNA Construction
mRNAs-ac4C-TRMT6/61A-YTHDF1/2/3-ALKBH7-PDH-TET
Substrates
SAM
Cofactors
ADP
Pathway
Mevalonate pathway
Epigenetic regulator
NSD2 overexpression
Metabolic alteration
Upregulating pentose phosphate pathway
Targeting diseases
Esophageal Cancers
RNA-binding proteins
MBNL
Metabolic Reprogramming
Mevalonate pathway-MBNL-SAM-ADP
Target
HIF-1
Alternative Names
Hypoxia-inducible factor 1 (HIF1
Format
Liquid
Shipping
All ordered products are shipped from Fedex or UPS.
Handling Advice
Prevent prolonged exposure to light.
Storage
Recommended long-term storage in - 20 ° C, to ensure the longest shelf life of products.
For Research Use Only | Not For Clinical Use
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