Human CD155 Recombinant Cell Line, HEK293 (CAT#: IOC-LX076)

Creative Biolabs has developed several immune checkpoint stable cell Lines expressing the most popular immune checkpoints to accelerate clients' immunotherapy discovery and clinical translation. Recombinant HEK293 cell line expressing full length human CD155, also known as poliovirus receptor (PVR) or nectin-like molecule-5 (NECL-5). Which can be used in binding assays and functional assay.

Stable cell lines for increased reliability and reproducibility;
Protein expression at the cell surface validated by FACS or WB;

The CD155/HEK293 Stable Cell Line functions as an antigen-presenting cell (APC) to stimulate TIGIT-specific signaling responses in lymphocytes, such as cell proliferation and cytokine release, or with a TIGIT reporter cell line.

Human

HEK293

CD155

CD155 is a transmembrane glycoprotein receptor belonging to the immunoglobulin superfamily. It is highly expressed on dendritic cells, fibroblasts, endothelial cells, and multiple tumor cells including ovarian carcinoma, non-small cell lung, glioblastoma, and colorectal carcinoma. It has a high affinity for a T cell regulatory transmembrane surface protein called TIGIT (T cell immunoglobulin and ITIM domains), and plays a key role in tumor cell invasion and migration. Interaction between CD155 and TIGIT causes immunosuppressive effects on CD4+ and CD8+ T cells, which hinders T cell proliferation and function.