Human LAG3 ELISA Kit, Lot 21AO-164 [Cancer Immune Checkpoint Assay Kit] (CAT#: IOK-05-P075)

Micro ELISA Plate
Lyophilized Standard
Sample / Standard dilution buffer
Biotin- detection antibody (Concentrated)
Antibody dilution buffer
HRP-Streptavidin Conjugate (SABC)
SABC dilution buffer
TMB substrate
Stop Solution
Wash buffer (25X)
Plate sealers

< 46.875 pg/mL

Pre-coated

Intra-Assay: CV < 8%, Inter-Assay: CV < 10%

4 °C

6 months

For Research Use only

Lymphocyte Activation Gene 3 (LAG3)

CD223; LAG-3; Ly66; lymphocyte activating 3; lymphocyte-activation gene 3; LAG3; Lag3

Lymphocyte-activation gene 3 (LAG3) is a cell surface molecule with diverse biologic effects on T cell function. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.

3902

P18627

Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints