Human OX40 Recombinant Cell Line, HEK293 (CAT#: IOC-LX083)

Creative Biolabs has developed several immune checkpoint stable cell Lines expressing the most popular immune checkpoints to accelerate clients' immunotherapy discovery and clinical translation. Recombinant HEK293 stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327). Which can be used in binding assays and functional assay.

Stable cell lines for increased reliability and reproducibility;
Protein expression at the cell surface validated by FACS or WB;

OX40 binding molecule (such as anti-OX40 antibody) screening and profiling in a cellular context.

Human

HEK293

OX40

OX40 (CD134) is a co-stimulatory receptor expressed on the surface of CD4+ and CD8+ T cells 24 to 48 hours after activation. Binding of OX40 to its ligand, OX40L (CD252), present on dendritic cells, potentiates T cell survival and increases cytokine production. OX40 has been shown to activate NF-κB-mediated memory cell generation through its interaction with adaptor proteins TRAF2 and TRAF5. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response.