T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT)
Synonyms
VSIG9; VSTM3; WUCAM; ENSMUSG00000071552; Vstm3; RGD1563191; T-cell immunoreceptor with Ig and ITIM domains; T cell immunoreceptor with Ig and ITIM domains; TIGIT; Tigit
Background
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an immune receptor present on some T cells and Natural Killer Cells. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-specific CD8+ T cells and CD8+ tumor infiltrating lymphocytes from individuals with melanoma .