Creative Biolabs has developed a wide range of humanized mice models, which harbor human immune cells as powerful tools to study potential cancer immunotherapies except for cell line derived xenografts (CDX) and patient derived xenografts (PDX) models. We provide on-the-shelf inventories of versatile humanized models that have been adapted to the preclinical testing of immunotherapy agents.
The major drawback of cell line derived xenografts (CDX) and patient derived xenografts (PDX) models is the lack of an immunocompetent host, while immunotherapy is based on manipulation of the immune system to fight cancer. Here, as a breakthrough platform, humanized mice models can generate functional human immune systems with expanding ability.
Fig.1 Humanized mice models.
Our scientists established the following humanized mice models to support your immuno-oncology research.
To facilitate the analysis of the safety and efficacy outcomes of potential novel agents modulating the immune system, Creative Biolabs offers humanized CD34+ mice as a robust in vivo model for long-term immuno-oncology studies.
It has been characterized as a functional human immune system when this in vivo model is implanted with cord blood-derived hematopoietic stem cells (HSC), and robust T-cell maturation and T-cell dependent inflammatory responses also have been confirmed.
Humanized PBMC mice is another in vivo model with the highest engraftment rate using adult peripheral blood mononuclear cells. It has been characterized as a functional human immune system displaying strong effector and memory T cells and NK cells function in short-term studies.
They are all available for immediate delivery to your facility or enrollment in our preclinical pharmacology and efficacy studies.
Humanized mice harbor human immune cells, which can be induced to produce immune response by immunotherapy. This kind of animal model has been used to detect compounds that manipulate the immune system to attack cancer. It makes up for the shortcomings of patient-derived and traditional xenografts lacking immunocompetent hosts. These humanized mice models can be combined with the following tools to enhance the study outcomes and advance your programs.
Creative Biolabs has validated all the models available, and we are committed to accelerating your immuno-oncology studies and offering the most appropriate in vivo model for next stage preclinical testing. Please contact us for more information.
Reference
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