PharmaOnco™ CHIR 99021

CAT#: ITS-0622-YT329
Product Type: Small Molecules
Product Overview
CHIR99021 is a chemical compound which acts as an inhibitor of the enzyme GSK-3, both GSK3β (IC₅₀ = 6.7 nM) and GSK3α (IC₅₀ = 10 nM). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells.
Applications
Cell Expansion and Differentiation, Reprogramming
Size
1 mg
Chemical Name
6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Cell Type
Cardiomyocytes, PSC-Derived, Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mesoderm, PSC-Derived, Neural Cells, PSC-Derived, Neurons, Pancreatic Cells, Pluripotent Stem Cells
Pathway
WNT
Target
GSK3
Subtype
GSK-3 Inhibitor
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
Shelf Life
Stable for 12 months from date of receipt.
Storage
Store at -20°C. Protect from prolonged exposure to light.
Molecular Weight
465.3 g/mol
Format
Solid
For Research Use Only | Not For Clinical Use
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