Product Overview
CHIR99021 is a chemical compound which acts as an inhibitor of the enzyme GSK-3, both GSK3β (IC₅₀ = 6.7 nM) and GSK3α (IC₅₀ = 10 nM). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells.
Applications
Cell Expansion and Differentiation, Reprogramming
Chemical Name
6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Cell Type
Cardiomyocytes, PSC-Derived, Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mesoderm, PSC-Derived, Neural Cells, PSC-Derived, Neurons, Pancreatic Cells, Pluripotent Stem Cells
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
Datasheet