PharmaOnco™ D4476

CAT#: ITS-0622-YT325
Product Type: Small Molecules
Product Overview
D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC50 value of 0.3 μM in vitro. It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with an IC50 value of 0.5 μM.
Applications
Cell Expansion and Differentiation, Reprogramming
Size
5 mg
Chemical Name
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Cell Type
Hematopoietic Stem and Progenitor Cells, Pluripotent Stem Cells
Pathway
Activin/Nodal/TGFβ, p38 MAPK
Target
CK1, ALK5
Subtype
CK1 Inhibitor
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
Shelf Life
Stable for 12 months from date of receipt.
Storage
Store at -20°C
Molecular Weight
398.4 g/mol
Format
Solid
Formulation
The IC50s of inhibiting CK1 and ALK5 is 0.3 and 0.5 μM, respectively.
For Research Use Only | Not For Clinical Use
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