SB 216763 is a potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 34.3 nM for GSK-3α). Equally effective at inhibiting human GSK-3α and GSK-3β. It can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). SB216763 activates autophagy.
Cancer Cells and Cell Lines, Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Myogenic Stem and Progenitor Cells, Neural Stem and Progenitor Cells, Pluripotent Stem Cells
Pathway
WNT
Target
GSK
Subtype
GSK Inhibitor
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
Shelf Life
Stable for 12 months from date of receipt.
Storage
Store at -20°C. Protect from prolonged exposure to light.
