PharmaOnco™ StemRegenin 1

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemRegenin 1 induces CD34+ cell expansion by binding and antagonizing AhR. It is reported to promote the self-renewal of human hematopoietic stem cells in culture by sustaining the cellular expression of CD34. StemRegenin 1 also promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

Cell Expansion and Differentiation

1 mg

4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol

Cancer Cells and Cell Lines, Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Leukemia/Lymphoma Cells, Pluripotent Stem Cells

AHR

AHR

AHR Inhibitor

Immunology

Restrictions for research use only. Intended for use by laboratory professionals.

Stable for 12 months from date of receipt.

Store at -20°C

429.5 g/mol

Solid