Product Overview
StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemRegenin 1 induces CD34+ cell expansion by binding and antagonizing AhR. It is reported to promote the self-renewal of human hematopoietic stem cells in culture by sustaining the cellular expression of CD34. StemRegenin 1 also promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
Applications
Cell Expansion and Differentiation
Chemical Name
4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol, monohydrochloride
Cell Type
Cancer Cells and Cell Lines, Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Leukemia/Lymphoma Cells, Pluripotent Stem Cells
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
Datasheet