Valproic acid (VPA; 2-Propylpentanoic Acid) is a branched short-chain fatty acid (SCFA) made from valeric acid. It is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. VPA can also increase γaminobutyric acid (GABA) levels via inhibition of enzymes involved in GABA metabolism.
Applications
Cell Expansion and Differentiation, Reprogramming
Size
500 mg
Chemical Name
Sodium 2-propylpentanoate
Cell Type
Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Neurons, Osteoblasts, Pluripotent Stem Cells
Target
HDAC
Subtype
HDAC Inhibitor
Area of Interest
Immunology
Limitation
Restrictions for research use only. Intended for use by laboratory professionals.
