Measures the frequency of cytokine-secreting cells at a single-cell level, providing a highly sensitive readout of T-cell and B-cell activation.
Learn More →Creative Biolabs provides clear and actionable solutions for your immuno-oncology projects, helping you validate your therapeutic's mechanism of action, optimize lead candidates, and assess potential toxicity. Our capabilities are specifically designed to address key challenges in the field, such as therapeutic resistance and the complex interplay between immune cells and tumor cells. We help you move beyond simple viability assays to obtain a holistic understanding of your candidate's biological activity in a physiologically relevant context.
Immuno-oncology is a transformative field that leverages the power of the body's immune system to fight cancer. The central challenge lies in understanding how to "unmask" tumors that have evolved mechanisms to evade immune attack. Immuno-oncology cell-based assays are essential for studying these complex interactions, bridging the gap between theoretical drug design and clinical application. By providing a platform for early drug discovery and validation, these assays are crucial for identifying promising candidates and de-risking the development pipeline.
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Fig.1 The Immune system can eliminate tumor cells by self-sustaining and self-restricting feedback loops.1
Creative Biolabs has over a decade of proven expertise in the research of cell-based assays. Our service offering comprises full cell-based assay analytical methods.
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Measures the frequency of cytokine-secreting cells at a single-cell level, providing a highly sensitive readout of T-cell and B-cell activation.
Learn More →A multi-parameter version of the ELISPOT, allowing for the simultaneous detection of multiple cytokines or proteins secreted by the same cell, offers a more nuanced view of the immune response.
Learn More →Our service includes advanced cell culture techniques, including the use of proprietary cell lines, cryopreservation, and mycoplasma testing, to ensure the integrity and quality of your cellular models.
Learn More →Utilizes high-throughput flow cytometry for rapid and precise analysis of immune cell populations, phenotyping, and the expression of activation or exhaustion markers.
Learn More →Measures the activity of specific kinases, which are critical signaling molecules in both immune and tumor cells, providing insight into the mechanism of action of small molecule inhibitors.
Learn More →High-throughput screening (HTS) has been widely applied in discovery and drug development, which is a challenging process characterized by expense and time-consuming, full of failures. Cell-based assays have been integrated with HTS technologies, which are unable to reflect the complexity of living systems. To address this problem, in vitro cell culture models are used to get substantive information on various cellular responses to a compound. Combining advanced microscopy with cell-based assays can monitor both spatial and temporal resolution, which has driven the development of HCS technologies. Cell assays can accelerate and enhance the process of drug identification and development to help new therapeutics be brought to market in an efficient manner.
Blew is HCS-compatible, biochemical, and molecular biology-driven assays for drug discovery, which are available at Creative Biolabs.
Quantification of drug target proteins
Identification of subcellular localization
Phenotypic characterization
Cell-ECM interaction studies
Functional genomics
Validation of new targets
Therapeutic drug repositioning
Studies for gene expression and regulation
Phenotypic characterization
Mechanism-based toxicity assays
Cell-cell and cell-ECM interaction studies
Functional genomics
Phenotypic characterization
Quantification of target proteins
Identification of protein-protein interactions
Identification of small-molecule-targeted pathways
Identification of novel targets
Discover how a partnership with us can streamline your research - Get a quote today.
Yes, our services are highly flexible. We work closely with our clients to design and validate custom assays using your proprietary compounds, unique cell lines, and specific endpoints to ensure the data directly addresses your research question.
We adhere to strict quality control protocols, including the use of validated cell models, standardized operating procedures, and state-of-the-art automated platforms to minimize variability. All data undergoes rigorous statistical analysis to ensure reproducibility and accuracy.
Our specialized service uses advanced multiplex IHC and digital image analysis to identify and quantify multiple biomarkers on a single tissue sample, providing a comprehensive profile of the tumor microenvironment and informing patient stratification.
Learn More →Assess the critical immune mechanisms of your therapeutic antibodies through our validated and high-throughput assays for Antibody-dependent cellular cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC), and Antibody-dependent cellular phagocytosis (ADCP).
Learn More →Creative Biolabs provides a comprehensive array of validated cell-based assays and full support for drug development. We work with our clients to come up with the best assay for the proposal. Please contact us for more detailed information on cell-based assays.
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