Immuno-oncology Receptor Occupancy (RO) Measurement Service

Empowering Precision in Immunotherapy through RO Insights

Receptor Occupancy (RO) is a critical pharmacodynamic biomarker that quantifies the binding of a therapeutic to its target on a cell surface, providing essential insights into a drug's mechanism of action and dose-response relationship. Creative Biolabs offers an advanced Immuno-oncology RO measurement service tailored to dissect these crucial interactions. By quantifying receptor engagement, we unveil critical insights into the efficacy and mechanisms of action of immunotherapeutic agents, facilitating the optimization of therapeutic strategies for combating cancer.

To explore how our services can support your project, request a consultation.

Fig.1 Three general types of ROA measurements: the measurements of free receptor, total receptor, and bound receptor. (Creative Biolabs Original)

Fig.1 Three types of measurements for flow-based ROA.

What We Can Offer

Specific Services	Description and Features
Receptor Occupancy Assays	Leveraging cutting-edge techniques like Flow Cytometry-based or ligand-binding assays, we quantitatively measure the occupancy of immune receptors by therapeutic agents.
Dose-response Analysis	Our service encompasses dose-response studies to evaluate receptor occupancy across a spectrum of drug concentrations, enabling the determination of optimal dosing regimens.
Customized Assay Development	We specialize in tailoring assay protocols to specific receptors and therapeutic agents, ensuring precise and reliable measurements.
Comprehensive Data Analysis	Our analysis includes comprehensive data interpretation, encompassing dose-response curves, EC50 determination, and robust statistical analysis to facilitate informed decision-making.

Highlights

Quantitative Precision

We deliver precise measurements of receptor occupancy, thereby enabling a quantitative evaluation of drug-target interactions. Our advanced technological capabilities and rigorous methodologies ensure the accuracy of every data point, which in turn facilitates confident, informed decision-making during drug development.

Customization

Our assay protocols are meticulously tailored to specific receptors and therapeutic agents. This bespoke approach ensures the relevance and accuracy of all data, providing a precise fit for each unique project. The avoidance of standardized, one-size-fits-all solutions is a core tenet of our service.

Comprehensive Insights

Beyond raw numerical data, we offer in-depth data analysis and interpretation. Our expert team translates complex findings into clear, actionable insights, empowering clients to make well-informed decisions throughout the drug development and research processes.

Expertise and Support

Clients benefit from our team's unparalleled expertise and access to state-of-the-art facilities. We consistently deliver reliable and high-quality results, supported by a steadfast commitment to providing full scientific guidance throughout the entire project lifecycle.

To receive a comprehensive proposal- Get a quote today.

Customer Reviews

Increased Efficiency
The reproducibility of Creative Biolabs' RO assays is a game-changer. We've used their service for a multi-center global trial, and the data consistency across different labs has been essential for our analysis, minimizing the risk of false data interpretation. - Jn De.

Comprehensive Support
We were able to address a significant technical challenge with our program by partnering with Creative Biolabs. Their team identified a key discrepancy in our initial measurements caused by receptor internalization and helped us develop a more robust assay. - Me Ln.

FAQs

Why is Receptor Occupancy measurement important for my drug development program?

RO measurement is crucial because it provides direct evidence that your drug is engaging its intended target at the cellular level. This information is vital for selecting the optimal dose, predicting efficacy, and making informed decisions that can accelerate your path to market.

Can you develop an assay for a novel or difficult-to-target receptor?

Absolutely. Our team specializes in custom assay development. We thrive on a challenge and are experts at designing bespoke assays for novel targets, including those with low expression or complex binding kinetics. We will work closely with you to create a solution tailored to your unique molecule.

Related Services

Biomarker Development Service

Provides an end-to-end solution for biomarker identification, assay development, and validation to support key decisions in your drug discovery and development pipeline.

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Immuno-oncology Phospho-flow Cytometry Service

Delve into intracellular signaling pathways by measuring the phosphorylation status of key signaling molecules. This service goes beyond surface markers to provide insights into a drug's downstream biological effects, complementing RO measurement.