In Vivo Drug Metabolism and Pharmacokinetics (DMPK) Service

As an experienced end-to-end CRO in the field of cancer immunotherapy discovery and development, Creative Biolabs has emerged as a stable and trusted partner to provide integrated drug metabolism and pharmacokinetics (DMPK) services to support pre-clinical testing. PK is a critical aspect of pharmacology related to the study of drug action in animal models.

Accelerate and Innovate Your DMPK Studies to Best Maximize
Your Cancer Immunotherapeutic Drug Candidate!

In Vivo DMPK Services

Pharmacokinetics describes plasma concentration changes over time as a consequence of absorption, distribution, metabolism, and excretion (ADME). Our in vivo DMPK services can seamlessly perform in vivo sample generation as well as bioanalysis to determine how the body reacts to the drug. Creative Biolabs can product DMPK studies in most rodent species, and owns various instruments and expertise in our bioanalytical lab to offer rapid and sensitive drug concentration measurements with various indicators.

We offer DMPK studies including:

  • PK modeling & simulation
  • Bioavailability/bioequivalence (BA/BE)
  • Food effect
  • Drug-drug interactions
  • Dose escalation
  • Thorough QT studies
  • Toxicokinetics (TK)
  • Mass Balance
  • MSD (Meso Scale Discovery) Assays
  • Pharmacokinetics-compartmental & noncompartmental analysis (NCA)
  • Tissue Distribution
  • First in human: Prediction of human PK

We offer DMPK Analysis:

The drug concentration-time profile data are modeled to determine PK parameters such as AUC, absorption, and elimination kinetics, t1/2, Cmax, Cmin, volume of distribution, and clearance rate using WinNonlin software (Pharsight Corporation, Mountain View, CA) or ADAPT-5 software (USC).

Carrying out the DMPK studies can establish dose range and administration schedule for subsequent clinical trials. Our team provides our clients with a smooth and seamless collaboration from drug candidates’ shipment to data processing. Also, our experts work closely with our clients to offer the integrated planning, implementation, feedback and guidance to advance their drug discovery projects about oncology immunotherapy.

Highlights

By outsourcing your DMPK studies to Creative Biolabs, we ensure:

  • Comprehensive studies to cover all your needs,
  • In industry-best timelines,
  • Reproducible and accurate DMPK data and shaping outcomes.

Creative Biolabs is dedicated to the success of the candidates at the clinical stages regardless of unpredictable metabolic, pharmacokinetic or toxicity properties. Leveraging on our PK services will help you make informed decisions. Our scientists are dedicated to both discovery and development which can allow hit optimization to flow seamlessly into the development phase. Please contact us for further communications to learn how Creative Biolabs can be involved in your project.

For Research Use Only | Not For Clinical Use

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