PharmaOnco™ HEK293-Tg(Human TLR5//CD14) Stable Cell Line, Cell Pool/Single Clone (CAT#: ITS-0822-HMM80)

Creative Biolabs offers HEK293-Tg(Human TLR5//CD14) stable cell line which the TLR5 and CD14 gene stably expressed in HEK293 cells.

Creative Biolabs offers the overexpression HEK293 cells stably expressing additional TLR or NOD genes.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

TLR5 and CD14

Human

HEK293

TLR5 is a receptor that recognizes flagellin, a protein component of bacterial flagella. Its activation leads to the activation of NF-κB and MAPK pathways, which induce the production of inflammatory cytokines and are essential for sensing flagellated bacteria and initiating the immune response against them.
CD14 is a glycoprotein primarily expressed on the surface of monocytes and macrophages, where it serves as a co-receptor for the recognition of pathogen-associated molecular patterns (PAMPs), particularly lipopolysaccharides (LPS) from Gram-negative bacteria. CD14 exists in two forms: a membrane-bound form and a soluble form. The membrane-bound CD14 facilitates the binding of LPS and other microbial components to the TLR4-MD2 complex, which is critical for initiating innate immune responses. This activation leads to the production of pro-inflammatory cytokines and helps mediate the body's response to infections and inflammation. CD14 also plays a role in modulating immune responses and maintaining immune homeostasis.