PharmaOnco™ CD137/NF-kappa B Reporter - HEK293 Recombinant Cell Line (Human)

Recombinant HEK293 cell line expressing a full length human CD137 (NM_003811). The NF-kappaB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-kappaB response element located upstream of the TATA promoter. Following activation by human CD137 ligand, NF-kappaB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.

Screen for activators or inhibitors of CD137 signaling in a cellular context Characterize the biological activity of CD137 and its interactions with ligands

Human

HEK293

CD137, 4-1BB

Kidney

2 vials

-80C

Store in liquid nitrogen immediately upon receipt.