Description
Recombinant HEK293 cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5; TNFRSF5). Expression is confirmed by real-time qPCR and Western Blot. This NF-kappaB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-kappaB response element located upstream of the TATA promoter. Following activation by human CD40 ligand, NF-kappaB transcription factor binds to the DNA response elements to induce transcription of the luciferase gene. ;
Applications
The CD40 NF-kappaB Reporter HEK293 Stable Cell Line is ideal for High Throughput Screening (HTS) to identify potential CD40 agonistic monoclonal antibodies and CD40-specific inhibitors.
Common Name
CD40 cell line, luciferase reporter, CD40 NF-kB cell line, NFkB cell line
Datasheet
