PharmaOnco™ CHO-Tg(Human CD19)-Luc Reporter Cell Line, Single Clone

CAT#: ITS-0822-HMM116
Product Type: Reporter Cell Line
Short Description
Creative Biolabs offers CHO-Tg(Human CD19)-Luc reporter cell line which the CD19 gene stably expressed in Luc reporter CHO cells.
Description
The CHO-Tg(Human CD19)-Luc reporter cell line is a cell line derived from Chinese hamster ovary cells (CHO) that has been genetically modified to express the human CD19 antigen and a luciferase reporter gene. The human CD19 antigen is a cell surface protein that is commonly used as a target for immunotherapy in the treatment of B-cell malignancies. This cell line is often used in research and drug development to study the mechanisms of immunotherapy and to screen for potential therapeutic agents targeting the CD19 antigen.
Features
Consistent gene expression;
Reliability and reproducibility;
Applications
Functional assay
Protein Target
CD19
Species
Human
Parental Cell Line
CHO
Gene
GenBank accession #NM_001192
Background
CD19 is a transmembrane protein that is involved in B cell receptor signaling and B cell development. It helps to activate B cells and plays a critical role in their survival and proliferation.
CD20 is also a transmembrane protein that is primarily expressed on the surface of B cells. It is involved in the regulation of B cell activation, differentiation, and antibody production. CD20 is a target for certain monoclonal antibody therapies used in the treatment of B cell-related diseases, such as certain types of lymphoma and autoimmune disorders.
Unit Size
1 x 10e6 cells/vial, Frozen
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Identity Testing
Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.
Virological Safety Testing
A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Mycoplasma Testing
The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.
Shipping
Dry Ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Warnings
Avoid multiple freeze/thaw cycles
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Quality Control
All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.
For Research Use Only | Not For Clinical Use
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