PharmaOnco™ CHO-Tg(Human FcGR3A) Stable Cell Line, Single Clone

Creative Biolabs offers CHO-Tg(Human FcGR3A) stable cell line which the FcGR3A gene stably expressed in CHO cells.

CHO-Tg(Human FcGR3A) stable cell line is a cell line derived from Chinese Hamster Ovary (CHO) cells that has been genetically engineered to express the human Fc gamma receptor 3A (FcGR3A). This cell line is stable, meaning that it maintains the expression of FcGR3A over multiple passages and can be used in various research applications. FcGR3A is a type of Fc gamma receptor that plays a role in immune responses, particularly in the activation of immune cells such as natural killer cells. The CHO-Tg(Human FcGR3A) stable cell line can be used to study the interactions between FcGR3A and its ligands, such as antibody-bound antigens or immune complexes. It can also be used to investigate the signaling pathways and functional consequences of FcGR3A activation. Additionally, this cell line can be used to produce recombinant proteins or antibodies with enhanced effector functions through FcGR3A-mediated mechanisms.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

FcGR3A

Human

CHO

The FcGR3A gene, also known as FCGR3A, encodes the Fc-gamma receptor IIIa protein, which is a cell surface receptor that plays a critical role in the immune system by binding to the Fc portion of antibodies. This receptor is primarily expressed on natural killer (NK) cells and a subset of macrophages, and is involved in mediating antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis of immune complexes. Mutations or variations in the FcGR3A gene can affect the binding affinity of the receptor for antibodies, leading to altered immune responses and susceptibility to certain diseases. For example, individuals with certain genetic variants of FcGR3A may have an increased risk of autoimmune disorders, infectious diseases, or cancer.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.