PharmaOnco™ CHO-Tg(Human HER2) Stable Cell Line, Single Clone

CAT#: ITS-0822-HMM165
Product Type: Stable Cell Line
Short Description
Creative Biolabs offers CHO-Tg(Human HER2) stable cell line which the HER2 gene stably expressed in CHO cells.
Description
CHO-Tg(Human HER2) stable cell line refers to Chinese hamster ovary cells that have been genetically modified to express high levels of the human epidermal growth factor receptor 2 (HER2) gene. HER2 is a protein that is overexpressed in certain types of cancer, particularly breast cancer, and is a target for anti-cancer therapies. These cells can be used in research to study the mechanisms of HER2 signaling, as well as testing the efficacy of HER2-targeted therapies.
Features
Consistent gene expression;
Reliability and reproducibility;
Applications
Functional assay
Protein Target
HER2
Species
Human
Parental Cell Line
CHO
Gene
Genbank NM_004448.2
Background
The HER2 gene (human epidermal growth factor receptor 2) is a gene that codes for a protein involved in cell growth and division. When the HER2 gene is mutated or amplified, it can lead to the overproduction of the HER2 protein, which can drive the growth of cancer cells in various types of cancer, such as breast cancer and gastric cancer. Testing for the HER2 gene status is an important component of cancer diagnosis and treatment, as it can help determine the best course of treatment, such as targeted therapy with drugs that specifically inhibit the HER2 protein.
Unit Size
1 x 10e6 cells/vial, Frozen
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Identity Testing
Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.
Virological Safety Testing
A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Mycoplasma Testing
The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.
Shipping
Dry Ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Warnings
Avoid multiple freeze/thaw cycles
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Quality Control
All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.
For Research Use Only | Not For Clinical Use
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