PharmaOnco™ CHO-Tg(Human PD-L2//TCR activator) Stable Cell Line, Single Clone (CAT#: ITS-0822-HMM197)

Creative Biolabs offers CHO-Tg(Human PD-L2//TCR activator) stable cell line which the PD-L2 and TCR activator gene stably expressed in CHO cells.

The CHO-Tg(Human PD-L2//TCR activator) stable cell line is a genetically engineered Chinese hamster ovary (CHO) cell line that has been modified to express a human PD-L2 protein and a T cell receptor (TCR) activator. PD-L2 is a protein that is known to inhibit T cell activation, while the TCR activator is designed to enhance T cell activation. This stable cell line can be used in research to study the interactions between PD-L2 and TCR signaling pathways, and to explore potential therapeutic strategies for modulating T cell activity in the context of cancer, autoimmune diseases, and other immune-related disorders.L113

Consistent gene expression;
Reliability and reproducibility;

Functional assay

PD-L2//TCR activator

Human

CHO

GenBank accession #NM_025239

The PD-L2 gene encodes a protein called programmed death-ligand 2, which is a ligand for the programmed cell death protein 1 (PD-1) receptor. This interaction plays a crucial role in the regulation of the immune response by preventing excessive activation of T cells and promoting immune tolerance. Dysregulation of the PD-L2 gene has been implicated in various autoimmune diseases and cancers, making it an important target for therapeutic interventions.
TCR (T cell receptor) activators are compounds or molecules that stimulate the activation of T cells in the immune system. T cells play a crucial role in the immune response by recognizing and attacking infected cells or foreign invaders. TCR activators can enhance the ability of T cells to detect and eliminate harmful pathogens or cancer cells.