PharmaOnco™ CHO-Tg(Human PD-L2//TCR activator) Stable Cell Line, Single Clone

Creative Biolabs offers CHO-Tg(Human PD-L2//TCR activator) stable cell line which the PD-L2 and TCR activator gene stably expressed in CHO cells.

The CHO-Tg(Human PD-L2//TCR activator) stable cell line is a genetically engineered Chinese hamster ovary (CHO) cell line that has been modified to express a human PD-L2 protein and a T cell receptor (TCR) activator. PD-L2 is a protein that is known to inhibit T cell activation, while the TCR activator is designed to enhance T cell activation. This stable cell line can be used in research to study the interactions between PD-L2 and TCR signaling pathways, and to explore potential therapeutic strategies for modulating T cell activity in the context of cancer, autoimmune diseases, and other immune-related disorders.L113

Consistent gene expression;
Reliability and reproducibility;

Functional assay

PD-L2//TCR activator

Human

CHO

GenBank accession #NM_025239

The PD-L2 gene encodes a protein called programmed death-ligand 2, which is a ligand for the programmed cell death protein 1 (PD-1) receptor. This interaction plays a crucial role in the regulation of the immune response by preventing excessive activation of T cells and promoting immune tolerance. Dysregulation of the PD-L2 gene has been implicated in various autoimmune diseases and cancers, making it an important target for therapeutic interventions.
TCR (T cell receptor) activators are compounds or molecules that stimulate the activation of T cells in the immune system. T cells play a crucial role in the immune response by recognizing and attacking infected cells or foreign invaders. TCR activators can enhance the ability of T cells to detect and eliminate harmful pathogens or cancer cells.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.