PharmaOnco™ HEK293-Tg(Human CD40)-NF-κB Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM127)

Creative Biolabs offers HEK293-Tg(Human CD40)-NF-κB reporter cell line which the CD40 gene stably expressed in NF-κB Luc reporter HEK293 cells.

The HEK293-Tg(Human CD40)-NF-κB reporter cell line is a stable cell line that has been engineered to express the human CD40 receptor and a reporter gene system for NF-κB activation. This cell line is commonly used in research studies to investigate the activation of the NF-κB signaling pathway in response to CD40 receptor stimulation.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

CD40

Human

HEK293

The CD40 gene encodes a cell surface receptor protein that is involved in immune system activation and regulation. When activated by its ligand CD40L (CD40 ligand), the CD40 receptor mediates a variety of immune responses, including B cell activation, T cell proliferation, and cytokine production. Mutations in the CD40 gene have been associated with immunodeficiency disorders and autoimmune diseases. Targeting the CD40 pathway has also been explored as a potential therapeutic strategy for cancer and other immune-related disorders.