PharmaOnco™ HEK293-Tg(Human GPRC5D) Stable Cell Line, Single Clone

CAT#: ITS-0822-HMM163
Product Type: Stable Cell Line
Short Description
Creative Biolabs offers HEK293-Tg(Human GPRC5D) stable cell line which the GPRC5D gene stably expressed in HEK293 cells.
Description
The HEK293-Tg(Human GPRC5D) stable cell line is a genetically modified cell line derived from human embryonic kidney (HEK) 293 cells that express the human GPRC5D gene. GPRC5D is a G protein-coupled receptor that is highly expressed in certain cancer types and has been studied as a potential target for cancer therapy. This cell line can be used for screening potential drug candidates, studying receptor-ligand interactions, and investigating the role of GPRC5D in cancer progression.
Features
Consistent gene expression;
Reliability and reproducibility;
Applications
Functional assay
Protein Target
GPRC5D
Species
Human
Parental Cell Line
HEK293
Gene
GenBank Accession #NM_018654.1
Background
The GPRC5D gene encodes a protein that is a member of the G-protein coupled receptor family. This gene is specifically expressed in the plasma cells of the immune system and has been implicated in various hematological cancers, such as multiple myeloma. Studies have shown that the GPRC5D gene may play a role in the survival and proliferation of cancer cells, making it a potential target for therapeutic intervention. Further research is ongoing to better understand the function of this gene and its implications for cancer treatment.
Unit Size
1 x 10e6 cells/vial, Frozen
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Identity Testing
Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.
Virological Safety Testing
A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Mycoplasma Testing
The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.
Shipping
Dry Ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Warnings
Avoid multiple freeze/thaw cycles
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Quality Control
All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.
For Research Use Only | Not For Clinical Use
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