PharmaOnco™ HEK293-Tg(Human RANK)-NF-κB Luc Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM199)

Creative Biolabs offers HEK293-Tg(Human RANK)-NF-κB Luc reporter cell line which the RANK gene stably expressed in NF-κB Luc reporter HEK293 cells.

The HEK293-Tg(Human RANK)-NF-κB Luc reporter cell line is a human embryonic kidney cell line that has been engineered to express the human RANK gene and a luciferase reporter gene under the control of the NF-κB pathway. RANK (Receptor Activator of Nuclear Factor κB) is a protein that plays a key role in regulating the NF-κB signaling pathway, which is involved in various cellular processes including inflammation, immune responses, and cell survival. This cell line can be used to study the activation of the NF-κB pathway in response to RANK signaling, as well as to screen for potential drugs or compounds that modulate this pathway.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

RANK

Human

HEK293

GenBank Accession #NM_003839.2

The RANK gene, also known as TNFRSF11A, codes for a protein called Receptor Activator of Nuclear Factor Kappa-B (RANK). RANK plays a crucial role in regulating bone metabolism and is essential for osteoclast differentiation and function. Mutations in the RANK gene have been associated with various bone disorders, such as osteopetrosis and Paget's disease of the bone. The RANK gene is considered to be of high importance in the regulation of bone health and is therefore ranked as a significant gene in the field of bone biology.