PharmaOnco™ HEK293-Tg(Human TLR8)-NF-κB Luc Reporter Cell Line, Single Clone

Creative Biolabs offers HEK293-Tg(Human TLR8)-NF-κB Luc reporter cell line which the TLR8 gene stably expressed in NF-κB Luc reporter HEK293 cells.

The HEK293-Tg(Human TLR8)-NF-κB Luc reporter cell line is a cell line derived from HEK293 cells that has been engineered to express human Toll-like receptor 8 (TLR8) and a luciferase reporter gene driven by the NF-κB promoter. TLR8 is a pattern recognition receptor that recognizes single-stranded RNA and activates signaling pathways that lead to the activation of the transcription factor NF-κB.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

TLR8

Human

HEK293

GenBank Accession No. NM_017442

TLR8 (Toll-like receptor 8) is a gene that encodes a protein involved in the immune response to bacterial and viral infections. TLR8 is a member of the Toll-like receptor family, which recognizes pathogen-associated molecular patterns (PAMPs) and triggers the release of inflammatory cytokines. TLR8 is primarily expressed in immune cells such as monocytes, macrophages, and dendritic cells. Mutations in the TLR8 gene have been associated with susceptibility to certain infections and autoimmune diseases. Research on TLR8 continues to uncover its role in the immune system and its potential as a target for therapeutic interventions.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.