PharmaOnco™ Jurkat-Tg(Human CD160)-NFAT Luc Reporter Cell Line, Single Clone

CAT#: ITS-0822-HMM113
Product Type: Reporter Cell Line
Short Description
Creative Biolabs offers Jurkat-Tg(Human CD160)-NFAT Luc reporter cell line which the CD160 gene stably expressed in NFAT Luc reporter Jurkat cells.
Description
The Jurkat-Tg(Human CD160)-NFAT Luc reporter cell line is a cell line derived from Jurkat cells that has been engineered to stably express a luciferase reporter gene under the control of the NFAT (nuclear factor of activated T-cells) response element. Additionally, these cells also express the human CD160 protein, which is a cell surface receptor that can modulate T cell activation and function. This cell line can be used to study the activation of the NFAT signaling pathway in response to various stimuli, such as T cell receptor engagement or cytokine signaling.L30
Features
Consistent gene expression;
Reliability and reproducibility;
Applications
Functional assay
Protein Target
CD160
Species
Human
Parental Cell Line
Jurkat
Gene
GenBank Accession # NM_007053
Background
The CD160 gene encodes a cell surface glycoprotein that is part of the immunoglobulin superfamily. It is also known as BY55 or Natural Killer Cell Receptor BY55. CD160 is primarily expressed on natural killer (NK) cells, as well as some T cells and subsets of intestinal intraepithelial lymphocytes. It is thought to play a role in immune regulation and activation, particularly in the context of NK cell-mediated cytotoxicity and cytokine production. Mutations or dysregulation of the CD160 gene have been associated with various immune-related diseases and conditions.
Unit Size
1 x 10e6 cells/vial, Frozen
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Identity Testing
Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.
Virological Safety Testing
A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Mycoplasma Testing
The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.
Shipping
Dry Ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Warnings
Avoid multiple freeze/thaw cycles
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Quality Control
All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.
For Research Use Only | Not For Clinical Use
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