PharmaOnco™ Jurkat-Tg(Human HVEM)-NF-κB Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM169)

Creative Biolabs offers Jurkat-Tg(Human HVEM)-NF-κB reporter cell line which the HVEM gene stably expressed in NF-κB Luc reporter Jurkat cells.

The Jurkat-Tg(Human HVEM)-NF-κB reporter cell line is a type of genetically engineered human T-cell line that expresses the human herpes virus entry mediator (HVEM) gene and contains a nuclear factor-kappa B (NF-κB) reporter system. HVEM is a cell surface receptor that plays a role in regulating immune responses, including T-cell activation and proliferation. This cell line is commonly used in research to study the molecular mechanisms underlying T-cell activation and the regulation of immune responses. It can be employed to investigate the effects of HVEM signaling on NF-κB activation, gene expression, and cytokine production. Additionally, this cell line can be used to screen potential drugs or compounds that target the HVEM-NF-κB signaling pathway for therapeutic purposes.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

HVEM

Human

Jurkat

GenBank Accession #NM_003820

The HVEM gene, also known as TNFRSF14 (tumor necrosis factor receptor superfamily member 14), encodes a protein that functions as a receptor for several ligands, including the TNF-related ligands LIGHT and LTα. HVEM is involved in the regulation of immune responses, inflammation, and cell survival. Mutations or dysregulation of the HVEM gene have been associated with various diseases, including autoimmune disorders, cancer, and inflammatory conditions. Targeting HVEM with specific therapies is being explored as a potential treatment strategy for these diseases.