PharmaOnco™ Jurkat-Tg(Human LILRB4)-NFAT Luc Reporter Cell Line, Single Clone

Creative Biolabs offers Jurkat-Tg(Human LILRB4)-NFAT Luc reporter cell line which the LILRB4 gene stably expressed in NFAT Luc reporter Jurkat cells.

Jurkat-Tg(Human LILRB4)-NFAT Luc reporter cell line is a stable cell line derived from Jurkat cells that overexpress the human LILRB4 receptor and contain a luciferase reporter gene driven by the NFAT (nuclear factor of activated T-cells) promoter. This cell line can be used to study the activation of the NFAT signaling pathway in response to LILRB4 receptor activation. This cell line may be useful for drug screening, pathway studies, and other research applications related to LILRB4 signaling and the NFAT pathway.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

LILRB4

Human

Jurkat

GenBank Accession #NM_001278426

The LILRB4 (Leukocyte Immunoglobulin-Like Receptor B4) gene encodes a protein that is a member of the immunoglobulin superfamily and is involved in the regulation of the immune response. LILRB4 is mainly expressed on myeloid cells and plays a role in modulating immune responses through inhibitory signaling pathways. It has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Mutations or dysregulation of the LILRB4 gene can impact immune function and contribute to the development of these diseases. Further research on the role of LILRB4 in immune regulation may lead to new therapeutic strategies for the treatment of these conditions.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.