PharmaOnco™ Raji-Tg(Human CD80//CD86) Stable Cell Line, Cell Pool/Single Clone (CAT#: ITS-0822-HMM61)

Creative Biolabs offers Raji-Tg(Human CD80//CD86) stable cell line which the CD80 and CD86 gene stably expressed in Raji cells.

Creative Biolabs offers the overexpression Raji cells that stably express immune checkpoints.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

CD80 and CD86

Human

Raji

CD80, also known as B7-1, is a co-stimulatory molecule expressed on the surface of antigen-presenting cells (APCs), including dendritic cells, macrophages, and B cells. It plays a critical role in the activation of T cells by providing essential secondary signals necessary for T cell proliferation and survival. CD80 binds to the CD28 receptor on T cells, enhancing their activation when antigen is presented through the T cell receptor (TCR). Additionally, CD80 can interact with CTLA-4, leading to negative signaling that inhibits T cell activation. This dual role makes CD80 essential for regulating the immune response, promoting effective T cell activation while also maintaining tolerance to prevent autoimmune reactions.
CD86, also known as B7-2, is another co-stimulatory molecule found on antigen-presenting cells, such as dendritic cells, macrophages, and B cells. Like CD80, CD86 binds to CD28 on T cells to provide crucial signals that enhance T cell activation, proliferation, and cytokine production. CD86 can also interact with CTLA-4, but it offers a more transient signal compared to CD80. This interaction allows for fine-tuning of T cell responses, acting as a facilitator for activating T cells during the immune response while contributing to regulation and prevention of excessive activation. Together, CD80 and CD86 are fundamental for the initiation and regulation of adaptive immune responses.