PharmaOnco™ THP-1-STAT3 Luc Reporter Cell Line, Single Clone

Creative Biolabs offers THP-1-Tg(Human STAT3)-Luc reporter cell line which the STAT3 gene stably expressed in Luc reporter THP-1 cells.

The THP-1-STAT3 Luc reporter cell line is a specialized cell line used in the study of the STAT3 signaling pathway. It is derived from the human monocytic leukemia cell line THP-1, which has been engineered to express a luciferase reporter gene under the control of STAT3-responsive elements. This cell line can be used to investigate the role of STAT3 in various cellular processes, such as inflammation, cancer, and immune response.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

THP-1

STAT3 Luc Reporter is a type of luciferase reporter gene that is used to study the activity of the transcription factor STAT3. STAT3 is a transcription factor that plays a key role in a variety of cellular processes, including cell growth, differentiation, and survival. By using the STAT3 Luc Reporter, researchers can measure the activity of STAT3 in cells by monitoring the expression of the luciferase gene, which is under the control of a STAT3-responsive promoter. This allows for the quantification of STAT3 activity in response to different stimuli or treatments, providing valuable insights into the signaling pathways regulated by STAT3.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.