MCF7 In Vitro Molecular Biology Assay (Angiogenesis)

This assay is to provide MCF7-based In Vitro Molecular Biology Assay (Angiogenesis) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

MCF7

Human

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman. MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. MCF7 are epithelial cells isolated from the breast tissue of a 69-year-old, White, female patient with metastatic adenocarcinoma. Use these cells in your breast cancer research.

MCF-7

Breast Adenocarcinoma

Oncology

In Vitro Molecular Biology Assay (Angiogenesis)

MCF7-cell based In Vitro Molecular Biology Assay (Angiogenesis)

Direct detection methods of factors effecting angiogenesis mainly include real-time PCR, western blotting and enzyme-linked immunosorbent assay (ELISA). JAG1, PECAM1, ANGPTL3, MMP2, MMP9, HAND2, TGFA, LAMA5, IL1B, FIGF, TIMP3, ANGPT1, LECT1, EREG and ANPEP are the key genes reported to control angiogenesis.

Angiogenesis Monitoring Assays

Local and regional metastasis is a life-threatening condition in cancer, which is hard to control with the available cancer treatment options. In metastasis, cancer cells move away from primary tumors and travel through the blood and lymphatic system and form new tumors on other parts. A vascular
network growth is important for cancer metastasis. Angiogenesis is a process that is known as the formation of new blood vessels with the help of existing blood vessels and angiogenesis has been reported to play a major role in cancer growth and metastasis. Tumors can send chemical signals to nearby normal tissues to stimulate angiogenesis. New blood vessels can feed growing tumors with nutrients and oxygen, allowing cancer cells to spread (metastasis).