MetaboStat™ Phase I Metabolic Stability Research Kit

CAT#: ITS-0326-YL43
Product Type: Assay Kit
Species: All Species
Brand: MetaboStat™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Evaluates Phase I metabolic stability via CYP450 oxidation.
Brand
MetaboStat™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This comprehensive research kit is designed to evaluate the Phase I metabolic stability of investigational compounds by facilitating cytochrome P450-mediated oxidation reactions. It includes a complete NADPH regenerating system and validated positive controls, eliminating tedious preparatory steps. When utilized with appropriate hepatic microsomes, this optimized system delivers highly reproducible clearance data, providing researchers with an efficient and reliable solution for early-stage in vitro pharmacokinetic profiling.
Features
Features a complete, ready-to-use NADPH regenerating system that eliminates tedious reagent preparation to ensure highly reproducible Phase I metabolic stability evaluations.
Process Relevance
Assessing phase I metabolic clearance to optimize lead compound stability and pharmacokinetic properties during screening.
Application Stage
Drug design, lead optimization, and preclinical research
Applications
Utilized for in vitro CYP450-mediated oxidation assays and metabolic stability screening using various hepatic microsome models.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Liver microsomes (human and various animal species)
Research Areas
Drug Metabolism; Pharmacokinetics; Pharmacology; Toxicology
Size
100 tests
Data Output Type
Quantitative chromatographic peak area
Species
All Species
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on dry ice under temperature-controlled conditions.
Background
Phase I metabolism constitutes the primary mechanism of xenobiotic biotransformation, largely driven by the cytochrome P450 enzyme superfamily. These enzymes introduce functional groups via oxidation, reduction, or hydrolysis, critically influencing the pharmacokinetic properties and metabolic fate of investigational compounds.
For Research Use Only | Not For Clinical Use
Online Inquiry