Microbiome engage in multifaceted interactions with their host, encompassing contact-dependent, contact-independent, and immune-mediated mechanisms. Therefore, microbiota may modulate tumor initiation, progression, and metastasis through pleiotropic effects. Creative Biolabs provides advanced metastatic tumor microbiome analysis to help you investigate the changes in microbial composition and function in metastatic cancers, elucidate the interactions between microbes and hosts based on our advanced multi-omics technologies and specialized bioinformatics analysis.

Microbiome: A Driver to Tumor metastases

The tumor microbiome is a complex ecosystem comprising bacteria, fungi, and viruses, which colonize both intra-tumoral and peritumoral niches. It represents a critical yet frequently neglected determinant in cancer progression. A variety of researches demonstrate that these microbial communities functionally engaged participants in the metastatic cascade. Our services are designed to pioneer this domain, delivering comprehensive characterization of the microbial landscape across primary and metastatic tumors.

Fig.1 The role of microbiome in tumor metastasis.¹

Metastatic Tumor Microbiome Analysis Services at Creative Biolabs

Creative Biolabs' metastatic tumor microbiome analysis services provide a comprehensive understanding of the microbial communities within tumors and their role in cancer progression and metastases. By profiling microbial signatures across matched primary and metastatic lesions or across longitudinal tumor specimens, our platform help you decipher the mechanistic contribution of the microbiome to metastatic progression, which is useful for discovering novel prognostic biomarkers and designing next-generation therapeutics.

Service Packages

To meet the diverse and evolving demands of contemporary research, Creative Biolabs has meticulously designed specialized service packages tailored to provide comprehensive solutions related to metastatic tumor microbiome analysis services:

• Metagenomic based Metastatic Tumor Microbiome Analysis Service

This service provides the comprehensive view of microbiome in metastatic tumor, which is useful for you to identify microbial species and their functional genes within tumor samples.

• Genomic based Metastatic Tumor Microbiome Analysis Service

This service delves into the microbial genome to identify microbial species and key features associated with tumor metastasis, therapeutic efficacy, and patient prognosis.

• Transcriptomic based Metastatic Tumor Microbiome Analysis Service

By leveraging transcriptomics, this service conducts a comprehensive analysis of RNA transcripts from both the microbiota and the host to elucidate the interactions between microbial communities and the host microenvironment. It is beneficial for you to identify the key signaling pathways through which microbes regulate tumor metastasis.

• Pan-Cancer based Metastatic Tumor Microbiome Analysis Service

This service perform a cross-tumor type analysis in order to identify common microbial signatures and mechanisms of metastasis across different cancer indications.

• Tumor-resident Microbiome Composition Analysis Service

Utilizing diverse microbiomic techniques, this service analyzes the microbial communities within tumor tissues, in order to determine their composition, diversity, and interactions with the host tumor microenvironment, which empowers you to elucidate the types and abundance of microbes, as well as their potential roles in tumor initiation, progression, and metastasis.

• Bacterial Composition & Tumor Gene Expression Correlation Analysis Service

This service integrates microbial profiling with host gene expression data to identify how bacteria influence key tumor pathways.

• Microbial Community & Host Immunity Correlation Analysis Service

This service focuses on the interactions between microbial communities and the host immune system, aiming to investigate how the composition and function of microbial communities influence host immune responses, and to develop novel immunotherapeutic strategies.

• Hypoxic Tumor Anaerobic Bacteria Analysis Service

This service is specifically designed to analyze the growth, distribution, and functional mechanisms of anaerobic bacteria in hypoxic tumor regions, with the aim of developing precision tumor-targeting therapeutic strategies.

• Time dependent Evolution Analysis Service for Microbial Community in Metastasis

This service employs a combination of longitudinal studies and multi-omics technologies to track the changes in microbial communities during tumor progression and metastasis, with the goal of identifying novel approaches to inhibit tumor metastasis.

• Therapeutic Pressure Impact Analysis Service for Bacterial Community

This service evaluates and analyzes the impact of various therapeutic interventions on the composition and function of microbial communities, in order to help you identify novel biomarkers for predicting treatment efficacy and develop innovative therapeutic strategies.

Workflow

• Step 1: Sample Acquisition and Preparation

Upon sample receipt, we conduct stringent quality-control assessments, and then we use standardized and contamination-minimized protocols to extract high-quality DNA/RNA.

• Step 2: Advanced Sequencing

We leverage cutting-edge sequencing modalities, such as metagenomic, genomic, and transcriptomic profiling, to interrogate both primary tumors and matched metastatic lesions with maximal resolution and quantitative precision.

• Step 3: Bioinformatics Analysis

We first harmonize multi-omics sequencing datasets through a rigorously validated integration pipeline, then apply state-of-the-art bioinformatic algorithms to extract biologically meaningful signals. This workflow precisely quantifies microbial composition, delineates abundance and functional disparities between primary lesions and metastatic sites, deciphers microbe–host interaction mechanisms, and ultimately pinpoints the pivotal signaling pathways driving tumoral progression.

• Step 4: Biomarker Discovery

By integrating microbial signatures with longitudinal clinical data, including cancer progression trajectories and patient outcomes, we systematically mine for predictive and prognostic biomarkers, helping you accelerate the development of new therapeutic strategies.

• Step 5: Data Interpretation and Reporting

Our multidisciplinary team of experts interprets the complex bioinformatic findings and distills them into a concise, clinically actionable report tailored to your research objectives.

FAQs

Why Choose Creative Biolabs

Creative Biolabs' metastatic tumor microbiome analysis services enable you to elucidate the alterations in microbial communities during metastasis, explore the interactions between microbes and the tumor microenvironment, and clarify the microbe–host interaction network. We assist you in discovering novel therapeutic targets, identifying potential prognostic biomarkers, and developing more effective treatment strategies. If you are interested in our metastatic tumor microbiome analysis services, please click the link to get in touch with us.

Reference

1. Ayabe, Reed I, and Michael G White. "Metastasis and the Microbiome: The Impact of Bacteria in Disseminated Colorectal Cancer." Frontiers in bioscience (Landmark edition) vol. 29,4 (2024): 152. doi:10.31083/j.fbl2904152. Distributed under Open Access License CC BY 4.0, without modification. DOI: https://doi.org/10.31083/j.fbl2904152

For Research Use Only | Not For Clinical Use